Dipon Ghosh, D, Sanders, T, Hong, S et al. (5 more authors) (2016) Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans. Neuron, 92 (5). pp. 1049-1062. ISSN 0896-6273
Abstract
Little is known about how animals integrate multiple sensory inputs in natural environments to balance avoidance of danger with approach to things of value. Furthermore, the mechanistic link between internal physiological state and threat-reward decision making remains poorly understood. Here we confronted C. elegans worms with the decision whether to cross a hyperosmotic barrier presenting the threat of desiccation to reach a source of food odor. We identified a specific interneuron that controls this decision via top-down extrasynaptic aminergic potentiation of the primary osmosensory neurons to increase their sensitivity to the barrier. We also establish that food deprivation increases the worm's willingness to cross the dangerous barrier by suppressing this pathway. These studies reveal a potentially general neural circuit architecture for internal state control of threat-reward decision making.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016 Elsevier Inc. This is an author produced version of a paper published in Neuron. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | decision making; multisensory integration; C. elegans; metabolism; neural circuits; neuromodulation |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Funding Information: | Funder Grant number EPSRC EP/J004057/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Dec 2016 16:46 |
Last Modified: | 17 Nov 2017 01:38 |
Published Version: | https://doi.org/10.1016/j.neuron.2016.10.030 |
Status: | Published |
Publisher: | Elsevier (Cell Press) |
Identification Number: | 10.1016/j.neuron.2016.10.030 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:109026 |