Clarke, Aimee K, Liddon, John T R, Cuthbertson, James D et al. (2 more authors) (2017) Dearomatisation approaches to spirocyclic dienones via the electrophilic activation of alkynes. Organic and Biomolecular Chemistry. pp. 233-245. ISSN 1477-0539
Abstract
Two complementary dearomatising spirocyclisation protocols to generate spirocyclic dienones from anisole and phenol-tethered ynones are described, each proceeding via electrophilic alkyne activation. The first approach focuses on the spirocyclisation of para-substituted anisoles using either SnCl2·2H2O or Cu(OTf)2. The second approach, which enables the spirocyclisation of both ortho- and para-substituted phenols, uses silica-supported AgNO3 to generate similar scaffolds with much greater efficiency. Initial asymmetric studies are also outlined.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, The Royal Society of Chemistry. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 05 Dec 2016 13:23 |
Last Modified: | 25 Mar 2025 00:07 |
Published Version: | https://doi.org/10.1039/c6ob02426b |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/c6ob02426b |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:108967 |
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