Suner, S, Gowland, N, Craven, R et al. (3 more authors) (2018) Ultrahigh Molecular Weight Polyethylene/Graphene Oxide Nanocomposites: Wear characterization and Biological Response to wear particles. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106 (1). pp. 183-190. ISSN 1552-4973
Abstract
In the field of total joint replacements, polymer nanocomposites are being investigated as alternatives to ultra high molecular weight polyethylene (UHMWPE) for acetabular cup bearings. The objective of the present study was to investigate the wear performance and biocompatibility of UHMWPE/graphene oxide (GO) nanocomposites. This study revealed that low concentrations of GO nanoparticles (0.5 wt%) do not significantly alter the wear performance of UHMWPE. In contrast, the addition of higher concentrations (2 wt%) led to a significant reduction in wear. In terms of biocompatibility, UHMWPE/GO wear particles did not show any adverse effects on L929 fibroblast and PBMNC viability at any of the concentrations tested over time. Moreover, the addition of GO to a UHMWPE matrix did not significantly affect the inflammatory response to wear particles. Further work is required to optimise the manufacturing processes to improve the mechanical properties of the nanocomposites and additional biocompatibility testing should be performed to understand the potential clinical application of these materials.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: 'Suñer, S, Gowland, N, Craven, R, Joffe, R, Emami, N, Tipper, JL 2016. Ultrahigh Molecular Weight Polyethylene/Graphene Oxide Nanocomposites: Wear characterization and Biological Response to wear particles. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106 (1). pp. 183-190,' which has been published in final form at https://doi.org/10.1002/jbm.b.33821. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | Total joint replacements; UHMWPE; graphene oxide; wear; cytotoxicity; tumor necrosis-α |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Nov 2016 12:39 |
Last Modified: | 26 Jan 2018 10:33 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/jbm.b.33821 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:108408 |