Shakoor, S, Zavos, HMS, Haworth, CMA et al. (4 more authors) (2016) Association between stressful life events and psychotic experiences in adolescence: evidence for gene-environment correlations. British Journal of Psychiatry, 208 (6). pp. 532-538. ISSN 0007-1250
Abstract
Background Stressful life events (SLEs) are associated with psychoticexperiences. SLEs might act as an environmental risk factor, but may also share a genetic propensity with psychotic experiences. Aims To estimate the extent to which genetic and environmental factors influence the relationship between SLEs and psychotic experiences. Method Self- and parent reports from a community-based twin sample (4830 16-year-old pairs) were analysed using structural equation model fitting. Results SLEs correlated with positive psychotic experiences (r = 0.12-0.14, all P50.001). Modest heritability was shown for psychotic experiences (25-57%) and dependent SLEs (32%). Genetic influences explained the majority of the modest covariation between dependent SLEs and paranoia and cognitive disorganisation (bivariate heritabilities 74-86%). The relationship between SLEs and hallucinations and grandiosity was explained by both genetic and common environmental effects. Conclusions Further to dependent SLEs being an environmental risk factor, individuals may have an underlying genetic propensity increasing their risk of dependent SLEs and positive psychotic experiences.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Psychiatry and Behavioural Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Nov 2016 12:02 |
Last Modified: | 15 Mar 2019 15:48 |
Published Version: | https://doi.org/10.1192/bjp.bp.114.159079 |
Status: | Published |
Publisher: | Royal College of Psychiatrists |
Identification Number: | 10.1192/bjp.bp.114.159079 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:108387 |