Johnson, S.L., Eckrich, T., Kuhn, S. et al. (8 more authors) (2011) Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells. Nature Neuroscience , 14 (6). pp. 711-717. ISSN 1097-6256
Abstract
Spontaneous action potential activity is crucial for mammalian sensory system development. In the auditory system, patterned firing activity has been observed in immature spiral ganglion and brain-stem neurons and is likely to depend on cochlear inner hair cell (IHC) action potentials. It remains uncertain whether spiking activity is intrinsic to developing IHCs and whether it shows patterning. We found that action potentials were intrinsically generated by immature IHCs of altricial rodents and that apical IHCs showed bursting activity as opposed to more sustained firing in basal cells. We show that the efferent neurotransmitter acetylcholine fine-tunes the IHC's resting membrane potential (Vm), and as such is crucial for the bursting pattern in apical cells. Endogenous extracellular ATP also contributes to the Vm of apical and basal IHCs by triggering small-conductance Ca2+-activated K+ (SK2) channels. We propose that the difference in firing pattern along the cochlea instructs the tonotopic differentiation of IHCs and auditory pathway.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2011 Nature America Inc. This is an author produced version of a paper subsequently published in Nature Neuroscience. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Spontaneous Discharge Patterns; Spiral Ganglion-Cells; Neurotransmitter Release; Developmental Regulation; Mammalian Cochlea; Ribbon Synapses; Auditory-System; Hearing; Expression; Channels |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 24 Nov 2016 14:06 |
Last Modified: | 21 Mar 2018 05:35 |
Published Version: | https://doi.org/10.1038/nn.2803 |
Status: | Published |
Publisher: | Nature Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1038/nn.2803 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:108206 |