Heymann, D. orcid.org/0000-0001-7777-0669, Brown, H.K. and Tellez-Gabriel, M. (2017) Cancer Stem Cells in Osteosarcoma. Cancer Letters, 386. pp. 189-195. ISSN 0304-3835
Abstract
Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Elsevier. This is an author produced version of a paper subsequently published in Cancer Letters. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Keywords: | Osteosarcoma; Bone cancer; Cancer stem cell; Tumour heterogeneity |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Funding Information: | Funder Grant number BONE CANCER RESEARCH TRUST BCRT 4516 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 23 Nov 2016 15:59 |
Last Modified: | 25 Nov 2017 01:38 |
Published Version: | https://doi.org/10.1016/j.canlet.2016.11.019 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.canlet.2016.11.019 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:108081 |