Sisley, K. orcid.org/0000-0002-5565-2618, Parsons, M. A., Garnham, J. et al. (4 more authors) (2000) Association of specific chromosome alterations with tumour phenotype in posterior uveal melanoma. British Journal of Cancer, 82 (2). pp. 330-338. ISSN 0007-0920
Abstract
Posterior uveal melanomas have recurrent alterations of chromosomes 1, 3, 6 and 8. In particular, changes of chromosomes 3 and 8 occur in association, appear to characterize those tumours with a ciliary body component, and have been shown to be of prognostic significance. The relevance of other chromosome alterations is less certain. We have performed cytogenetic analysis on 42 previously untreated primary posterior uveal melanomas. Of interest was the observation that as tumour size increased the involvement of specific chromosome changes, and the amount of chromosome abnormalities likewise increased. Loss, or partial deletions, of the short arm of chromosome 1 were found to associate with larger ciliary body melanomas; typically, loss of the short arm resulted from unbalanced translocations, the partners of which varied. Trisomy of chromosome 21 occurred more often in ciliary body melanomas, whilst rearrangements of chromosomes 6 and 11 were primarily related to choroidal melanomas. Our results imply that alterations of chromosome 1 are important in the progression of some uveal melanomas, and that other chromosome abnormalities, besides those of chromosomes 3 and 8, are associated with ocular tumours of particular locations.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016 Cancer Research UK. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
Keywords: | cytogenetics; translocation; uveal melanoma; phenotype; COMPARATIVE GENOMIC HYBRIDIZATION; EPIDEMIOLOGIC ASPECTS; CYTOGENETIC ANALYSIS; MALIGNANT MELANOMAS; ABNORMALITIES; IRIS; MONOSOMY-3; PROGNOSIS; GENES |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Nov 2016 14:31 |
Last Modified: | 21 Nov 2016 14:31 |
Published Version: | http://dx.doi.org/10.1054/bjoc.1999.0923 |
Status: | Published |
Publisher: | Cancer Research UK |
Refereed: | Yes |
Identification Number: | 10.1054/bjoc.1999.0923 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107965 |
Download
Filename: Association of specific chromosome alterations with tumour phenotype in posterior uveal melanoma.pdf
Licence: CC-BY-NC-SA 3.0