Gromnicova, R., Yilmaz, C. U., Orhan, N. et al. (6 more authors) (2016) Localization and mobility of glucose-coated gold nanoparticles within the brain. Nanomedicine, 11 (6). pp. 617-625. ISSN 1743-5889
Abstract
Aim: To identify the localization of glucose-coated gold nanoparticles within cells of the brain after intravascular infusion which may point to the mechanism by which they cross the blood–brain barrier. Materials & methods: Tissue distribution of the nanoparticles was measured by inductively-coupled-mass spectrometry and localization within the brain by histochemistry and electron microscopy. Results & conclusion: Nanoparticles were identified within neurons and glial cells more than 10 μm from the nearest microvessel within 10 min of intracarotid infusion. Their distribution indicated movement across the endothelial cytosol, and direct transfer between cells of the brain. The rapid movement of this class of nanoparticle (<5 nm) into the brain demonstrates their potential to carry therapeutic biomolecules or imaging reagents.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Future Medicine. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: | blood–brain barrier; brain; brain endothelium; cortex; drug delivery; glia; glyconanoparticles; gold nanoparticles; neurons; transmission electron microscopy |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Nov 2016 16:23 |
Last Modified: | 21 Nov 2016 16:23 |
Published Version: | http://dx.doi.org/10.2217/nnm.15.215 |
Status: | Published |
Publisher: | Future Medicine |
Refereed: | Yes |
Identification Number: | 10.2217/nnm.15.215 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107954 |