Simonini, S., Deb, J., Moubayidin, L. et al. (7 more authors) (2016) A noncanonical auxin-sensing mechanism is required for organ morphogenesis in Arabidopsis. Genes and Development, 30. pp. 2286-2296. ISSN 0890-9369
Abstract
Tissue patterning in multicellular organisms is the output of precise spatio–temporal regulation of gene expression coupled with changes in hormone dynamics. In plants, the hormone auxin regulates growth and development at every stage of a plant's life cycle. Auxin signaling occurs through binding of the auxin molecule to a TIR1/AFB F-box ubiquitin ligase, allowing interaction with Aux/IAA transcriptional repressor proteins. These are subsequently ubiquitinated and degraded via the 26S proteasome, leading to derepression of auxin response factors (ARFs). How auxin is able to elicit such a diverse range of developmental responses through a single signaling module has not yet been resolved. Here we present an alternative auxin-sensing mechanism in which the ARF ARF3/ETTIN controls gene expression through interactions with process-specific transcription factors. This noncanonical hormone-sensing mechanism exhibits strong preference for the naturally occurring auxin indole 3-acetic acid (IAA) and is important for coordinating growth and patterning in diverse developmental contexts such as gynoecium morphogenesis, lateral root emergence, ovule development, and primary branch formation. Disrupting this IAA-sensing ability induces morphological aberrations with consequences for plant fitness. Therefore, our findings introduce a novel transcription factor-based mechanism of hormone perception in plants.
Note that there is a CORRIGENDUM to this article: http://eprints.whiterose.ac.uk/132306/ http://genesdev.cshlp.org/content/31/17/1821.full
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Simonini et al. This article, published in Genes & Development , is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/. |
Keywords: | Arabidopsis; auxin signaling; IAA; plant development; transcription factor complex; ETTIN |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Nov 2016 13:50 |
Last Modified: | 06 Nov 2018 13:12 |
Published Version: | http://dx.doi.org/10.1101/gad.285361.116 |
Status: | Published |
Publisher: | Cold Spring Harbor Laboratory Press |
Refereed: | Yes |
Identification Number: | 10.1101/gad.285361.116 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107928 |