Meuth, M. (2010) Chk1 suppressed cell death. Cell Division, 5. 21. ISSN 1747-1028
Abstract
The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA replication or DNA damage. This review will consider these findings in the context of known pathways of Chk1 signalling and potential applications of therapies that target Chk1.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © Meuth; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | dna-damage response; double-strand breaks; homologous recombination; replication checkpoint; H2AX phosphorylation; tumor suppression; gins complex; in-vitro; s-phase; apoptosis |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 22 Nov 2016 15:50 |
Last Modified: | 22 Nov 2016 15:50 |
Published Version: | http://dx.doi.org/10.1186/1747-1028-5-21 |
Status: | Published |
Publisher: | BioMed Central |
Refereed: | Yes |
Identification Number: | 10.1186/1747-1028-5-21 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107900 |