Meuth, M. (2014) Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells. Molecular & cellular oncology, 1 (4). e968508. ISSN 2372-3556
Abstract
S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from our laboratory showed that tumor cells and more normal epithelial cells have a very different response to replication stress. In this Author's View, the implications of this finding are discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC© Mark Meuth. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
Keywords: | ATM; CHK1; DNA damage response; DNA replication; S-phase checkpoints; cell fate |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Nov 2016 15:38 |
Last Modified: | 23 Jun 2017 15:43 |
Published Version: | http://dx.doi.org/10.4161/23723548.2014.968508 |
Status: | Published |
Publisher: | Taylor&Francis |
Refereed: | Yes |
Identification Number: | 10.4161/23723548.2014.968508 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107898 |