Kanis, J. A., McCloskey, E. V., Powles, T. et al. (3 more authors) (1999) A high incidence of vertebral fracture in women with breast cancer. British Journal of Cancer, 79 (7-8). pp. 1179-1181. ISSN 0007-0920
Abstract
Because treatment for breast cancer may adversely affect skeletal metabolism, we investigated vertebral fracture risk in women with non-metastatic breast cancer. The prevalence of vertebral fracture was similar in women at the time of first diagnosis to that in an age-matched sample of the general population. The incidence of vertebral fracture, however, was nearly five times greater than normal in women from the time of first diagnosis [odds ratio (OR), 4.7; 95% confidence interval (95% CI), 2.3–9.9], and 20-fold higher in women with soft-tissue metastases without evidence of skeletal metastases (OR, 22.7; 95% CI, 9.1–57.1). We conclude that vertebral fracture risk is markedly increased in women with breast cancer.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 1999 Cancer Research Campaign. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
Keywords: | vertebral fracture; breast cancer; skeletal metastases; CLODRONATE; METASTASES; PREMENOPAUSAL; OSTEOPOROSIS; POPULATION; DENSITY; TRIAL |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 23 Nov 2016 09:26 |
Last Modified: | 23 Nov 2016 09:26 |
Published Version: | http://dx.doi.org/10.1038/sj.bjc.6690188 |
Status: | Published |
Publisher: | Nature Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1038/sj.bjc.6690188 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107897 |
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