Kitsara, M, Agbulut, O, Kontziampasis, D orcid.org/0000-0002-6787-8892 et al. (2 more authors) (2017) Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering. Acta Biomaterialia, 48. pp. 20-40. ISSN 1742-7061
Abstract
Cardiac cell therapy holds a real promise for improving heart function and especially of the chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better preserve cell survival and enhance cell engraftment after transplantation, consequently improving cardiac cell therapy compared with direct intramyocardial injection of isolated cells. The primary objective of a scaffold used in tissue engineering is the recreation of the natural 3D environment most suitable for an adequate tissue growth. An important aspect of this commitment is to mimic the fibrillar structure of the extracellular matrix, which provides essential guidance for cell organization, survival, and function. Recent advances in nanotechnology have significantly improved our capacities to mimic the extracellular matrix. Among them, electrospinning is well known for being easy to process and cost effective. Consequently, it is becoming increasingly popular for biomedical applications and it is most definitely the cutting edge technique to make scaffolds that mimic the extracellular matrix for industrial applications. Here, the desirable physico-chemical properties of the electrospun scaffolds for cardiac therapy are described, and polymers are categorized to natural and synthetic.Moreover, the methods used for improving functionalities by providing cells with the necessary chemical cues and a more in vivo- like environment are reported.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, Elsevier. This is an author produced version of a paper published in Acta Biomaterialia. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Electrospinning; Tissue engineering; Cardiac cells; Heart therapy; Biopolymers; Functional scaffold; Surface modification |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Nov 2016 16:22 |
Last Modified: | 06 Nov 2017 01:38 |
Published Version: | https://doi.org/10.1016/j.actbio.2016.11.014 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.actbio.2016.11.014 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107447 |