Malicki, J.J. and Johnson, C.A. (2017) The Cilium: Cellular Antenna and Central Processing Unit. Trends in Cell Biology, 27 (2). pp. 126-140. ISSN 0962-8924
Abstract
Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory inputs that are related to the cell cycle, cytoskeleton, proteostasis, and cilia-mediated signaling itself. Ciliogenesis and cilia maintenance are regulated by reciprocal antagonistic or synergistic influences, often acting in parallel to each other. By receiving parallel inputs, cilia appear to integrate multiple signals into specific outputs and may have functions similar to logic gates of digital systems. Some combinations of input signals appear to impose higher hierarchical control related to the cell cycle. An integrated view of these regulatory inputs will be necessary to understand ciliogenesis and its wider relevance to human biology.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | primary cilium; ciliogenesis; cell cycle; actin cytoskeleton; mTOR pathway; autophagy |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Funding Information: | Funder Grant number NATIONAL INSTITUTE OF HEALTH - UNITED STATES OF AMERICA 7R01EY018176-07 NATIONAL INSTITUTE OF HEALTH - UNITED STATES OF AMERICA 2R01EY018176-5 NATIONAL INSTITUTE OF HEALTH - UNITED STATES OF AMERICA 7R01EY018176-06 NATIONAL INSTITUTE OF HEALTH - UNITED STATES OF AMERICA 7R01EY018176-08 MEDICAL RESEARCH COUNCIL MR/N000714/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Nov 2016 13:38 |
Last Modified: | 18 Jul 2017 14:12 |
Published Version: | http://dx.doi.org/10.1016/j.tcb.2016.08.002 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.tcb.2016.08.002 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107408 |