Egner, W. orcid.org/0000-0002-2654-9881 (2017) Adherence to recommended UK sampling protocols for detecting mast cell mediator release in perioperative anaphylaxis. Journal of Clinical Pathology, 70 (1). pp. 85-88. ISSN 0021-9746
Abstract
Background Sheffield National Adverse Reactions Consultancy Service (NARCOS) investigates and triages suspected perioperative anaesthetic reactions to allergy clinics, using serial tryptase samples, urinary methylhistamine and clinical information on a pro forma request.
Objective To determine if current UK guidelines on serial tryptase samples are achieved and describe the patterns of tryptase release.
Method A retrospective review of 3455 NARCOS cases. Tryptase and clinical details were analysed. 1746 had sufficient clinical information to grade the reactions according to the Ring and Messmer scale.
Results 98% provided two or more acute samples, but only 60% supplied clinical information. 308 patients never dropped within the reference range over three samples.
Conclusions Good compliance with UK guidelines for tryptase measurements is achievable in this long-term cohort, but obtaining clinical details at referral remains a challenge. Sample sequence labelling and apparent timing may be misleading. Baseline tryptase may frequently need to be rechecked in allergy clinics to estimate true peak-to-trough changes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © BMJ Publishing Group, 2016. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 01 Dec 2016 16:10 |
Last Modified: | 14 Nov 2017 10:15 |
Published Version: | https://doi.org/10.1136/jclinpath-2016-204038 |
Status: | Published |
Publisher: | BMJ Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1136/jclinpath-2016-204038 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107293 |