Schmidt, R. orcid.org/0000-0002-2474-3744 and Berke, J.D. (2017) A Pause-then-Cancel model of Stopping: Evidence from Basal Ganglia Neurophysiology. Philosophical Transactions of the Royal Society B: Biological Sciences, 372. ISSN 0962-8436
Abstract
Many studies have implicated the basal ganglia in the suppression of action impulses ("stopping"). Here we discuss recent neurophysiological evidence that distinct hypothesized processes involved in action preparation and cancellation can be mapped onto distinct basal ganglia cell types and pathways. We examine how movement-related activity in the striatum is related to a “Go” process and how going may be modulated by brief epochs of beta oscillations. We then describe how, rather than a unitary “Stop” process, there appear to be separate, complementary “Pause” and “Cancel” mechanisms. We discuss the implications of these stopping subprocesses for the interpretation of the stop-signal reaction time – in particular, some activity that seems too slow to causally contribute to stopping when assuming a single Stop processes may actually be fast enough under a Pause-then-Cancel model. Finally, we suggest that combining complementary neural mechanisms that emphasize speed or accuracy respectively may serve more generally to optimize speed-accuracy trade-offs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Author(s). This is an author produced version of a paper subsequently published in Philosophical Transactions B: Biological Sciences. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Behavioural inhibition; striatum; subthalamic nucleus; stop-signal task; race model |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Nov 2016 13:33 |
Last Modified: | 27 Feb 2018 01:39 |
Published Version: | https://doi.org/10.1098/rstb.2016.0202 |
Status: | Published |
Publisher: | The Royal Society |
Refereed: | Yes |
Identification Number: | 10.1098/rstb.2016.0202 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107252 |