Dastgheib, S.A., Gartland, A., Tabei, S.M.B. et al. (2 more authors) (2016) A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population. Frontiers in Endocrinology, 7.
Abstract
The genetic epidemiology of variation in bone mineral density (BMD) and osteoporosis is not well studied in Iranian populations and needs more research. We report a candidate gene association study of BMD variation in a healthy cross-sectional study of 501 males and females sampled from the Iranian Multi-Centre Osteoporosis Study, Shiraz, Iran. We selected to study the association with 21 single nucleotide polymorphisms (SNPs) located in the 7 candidate genes LRP5, RANK, RANKL, OPG, P2RX7, VDR, and ESR1. BMD was measured at the three sites L2–L4, neck of femur, and total hip. Association between BMD and each SNP was assessed using multiple linear regression assuming an allele dose (additive effect) on BMD (adjusted for age and sex). Statistically signiicant (at the unadjusted 5% level) associations were seen with seven SNPs in ive of the candidate genes. Two SNPs showed statistically signiicant association with more than one BMD site. Signiicant association was seen between BMD at all the three sites with the VDR SNP rs731246 (L2–L4 p = 0.038; neck of femur p = 0.001; and total hip p = 0.045).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Dastgheib, Gartland, Tabei, Omrani and Teare. his is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). he use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms |
Keywords: | VDr, P2rX7; candidate gene association; BMD; genetic epidemiology; iranian population |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 11 Nov 2016 12:41 |
Last Modified: | 11 Nov 2016 12:41 |
Published Version: | https://doi.org/10.3389/fendo.2016.00141 |
Status: | Published |
Publisher: | Frontiers Media |
Refereed: | Yes |
Identification Number: | 10.3389/fendo.2016.00141 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107236 |