Santos, VS, Gurgel, RQ, Cavalcante, SMM et al. (9 more authors) (2017) Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil. Journal of Clinical Virology, 88. pp. 33-38. ISSN 1386-6532
Abstract
Background: Gastroenteritis is one of the most important causes of morbidity and mortality in children and an important etiological agent is norovirus. Objective: We describe the occurrence and characteristics of norovirus diarrhoea in children from Sergipe, Northeast-Brazil, over two consecutive periods of three years following rotavirus vaccine introduction. Study design: A cross sectional hospital-based survey conducted from October-2006 to September-2009 and from July-2011 to January-2013. Acute diarrhoea cases had a stool sample collected and tested for norovirus by RT-PCR and positive samples were sequenced. Results: In total 280 (19.6%) of 1432 samples were norovirus positive, including 204 (18.3%) of 1,113 samples collected during the first period and 76 (23.9%) of 318 collected during the second period. The proportion of children with norovirus infection increased significantly through the second study period (χ2 for trend = 6.7; p = 0.009), was more frequent in rotavirus vaccinated and in younger children (p < 0.001). Of 280 norovirus-positive specimens, 188 (67.1%) were sequenced. Of these, 12 were genogroup I and 176 genogroup II. The main genotype was GII.4 (149/188, 79.3%), followed by GII.2 (6, 3.2%) and GII.6 (5, 2.6%). Conclusion: Norovirus annual detection rates increased over the study period. The detection of norovirus was higher among young children.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, Elsevier. This is an author produced version of a paper published in Journal of Clinical Virology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | norovirus; diarrhoea; children; rotavirus vaccine; Brazil |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Nov 2016 15:24 |
Last Modified: | 31 Oct 2017 23:47 |
Published Version: | https://doi.org/10.1016/j.jcv.2016.10.015 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jcv.2016.10.015 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107140 |