El-Jawhari, JJ, Jones, E orcid.org/0000-0001-9365-2283 and Giannoudis, PV (2016) The roles of immune cells in bone healing; what we know, do not know and future perspectives. Injury, 47 (11). pp. 2399-2406. ISSN 0020-1383
Abstract
Key events occurring during the bone healing include well-orchestrated and complex interactions between immune cells, multipotential stromal cells (MSCs), osteoblasts and osteoclasts. Through three overlapping phases of this physiological process, innate and adaptive immune cells, cytokines and chemokines have a significant role to play. The aim of the escalating immune response is to achieve an osseous healing in the shortest time and with the least complications facilitating the restoration of function. The uninterrupted progression of these biological events in conjunction with a favourable mechanical environment (stable fracture fixation) remains the hallmark of successful fracture healing. When failure occurs, either the biological environment or the mechanical one could have been disrupted. Not infrequently both may be compromised. Consequently, regenerative treatments involving the use of bone autograft, allograft or synthetic matrices supplemented with MSCs are increasingly used. A better understanding of the bone biology and osteoimmunology can help to improve these evolving cell-therapy based strategies. Herein, an up to date status of the role of immune cells during the different phases of bone healing is presented. Additionally, the known and yet to know events about immune cell interactions with MSCs and osteoblasts and osteoclasts and the therapeutic implications are being discussed.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016, Elsevier. This is an author produced version of a paper published in Injury. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bone healing; Bone fracture; Immune cells; MSCs |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Orthopaedics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Nov 2016 14:04 |
Last Modified: | 02 Nov 2017 19:59 |
Published Version: | https://doi.org/10.1016/j.injury.2016.10.008 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.injury.2016.10.008 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107127 |