Beattie, R., Cummins, N., Caraher, C. et al. (7 more authors) (2016) Raman Spectroscopic Analysis of Fingernail Clippings Can Help Differentiate Between Postmenopausal Women Who Have and Have Not Suffered a Fracture. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 9. pp. 109-116. ISSN 1179-5441
Abstract
Raman spectroscopy was applied to nail clippings from 633 postmenopausal British and Irish women, from six clinical sites, of whom 42% had experienced a fragility fracture. The objective was to build a prediction algorithm for fracture using data from four sites (known as the calibration set) and test its performance using data from the other two sites (known as the validation set). Results from the validation set showed that a novel algorithm, combining spectroscopy data with clinical data, provided area under the curve (AUC) of 74% compared to an AUC of 60% from a reduced QFracture score (a clinically accepted risk calculator) and 61% from the dual-energy X-ray absorptiometry T-score, which is in current use for the diagnosis of osteoporosis. Raman spectroscopy should be investigated further as a noninvasive tool for the early detection of enhanced risk of fragility fracture.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © the authors, publisher and licensee Libertas Academica Limited. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
Keywords: | Fracture risk; Raman spectroscopy; QFracture, osteoporosis; bone; DEXA |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Nov 2016 10:15 |
Last Modified: | 14 Nov 2016 10:20 |
Published Version: | http://dx.doi.org/10.4137/CMAMD.S38493 |
Status: | Published |
Publisher: | Libertas Academica |
Refereed: | Yes |
Identification Number: | 10.4137/CMAMD.S38493 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107074 |