Khuphe, M orcid.org/0000-0002-6289-8675, Mahon, CS and Thornton, PD orcid.org/0000-0003-3876-1617 (2016) Glucose-bearing biodegradable poly(amino acid) and poly(amino acid)-poly(ester) conjugates for controlled payload release. Biomaterials Science, 4 (12). pp. 1792-1801. ISSN 2047-4830
Abstract
The glucoseamine-initiated ring-opening polymerisation of amino acid N-carboxyanhydrides and O-carboxanhydrides to yield amphiphilic block copolymers that are capable of self-assembly in aqueous solution to form well-defined, glucose-presenting, particles is reported. The particles formed are susceptible to enzyme-mediated (lipase and protease) and pH-induced degradation, and can selectively bind the lectin concanavalin A. Consequently, such glycoparticles are of significance for the controlled release of payload molecules in response to an acidic environment, for instance cancerous tissue, and upon interaction with target enzymes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2016. This is an author produced version of a paper published in Biomaterials Science. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Colour Science (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Oct 2016 10:11 |
Last Modified: | 03 Nov 2017 05:01 |
Published Version: | https://doi.org/10.1039/C6BM00535G |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/c6bm00535g |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:106537 |