Mao, Z., Chong, J. orcid.org/0000-0002-5846-7397 and Ong, A.C.M. (2016) Autosomal dominant polycystic kidney disease: recent advances in clinical management. F1000Research, 5. p. 2029. ISSN 2046-1402
Abstract
The first clinical descriptions of autosomal dominant polycystic kidney disease (ADPKD) go back at least 500 years to the late 16 century. Advances in understanding disease presentation and pathophysiology have mirrored the progress of clinical medicine in anatomy, pathology, physiology, cell biology, and genetics. The identification of PKD1 and PKD2, the major genes mutated in ADPKD, has stimulated major advances, which in turn have led to the first approved drug for this disorder and a fresh reassessment of patient management in the 21 century. In this commentary, we consider how clinical management is likely to change in the coming decade.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Mao Z et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 26 Oct 2016 14:49 |
Last Modified: | 26 Oct 2016 14:59 |
Published Version: | http://dx.doi.org/10.12688/f1000research.9045.1 |
Status: | Published |
Publisher: | F1000Research |
Refereed: | Yes |
Identification Number: | 10.12688/f1000research.9045.1 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:106464 |
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