Cu-catalysed pyrazole synthesis in continuous flow
Comas-Barceló, J., Blanco-Ania, D., van den Broek, S.A.M.W. et al. (3 more authors)
(2016)
Cu-catalysed pyrazole synthesis in continuous flow.
Catalysis Science and Technology, 6 (13).
pp. 4718-4723.
ISSN 2044-4753
Abstract
The synthesis of 1,4-disubstituted pyrazoles via the cycloaddition reaction of sydnones and terminal alkynes has been achieved employing silica-supported copper catalysts. Furthermore, this methodology has been successfully implemented in continuous flow conditions using prepacked stainless steel cartridges containing the solid-supported copper promoter. Finally, we demonstrate that this synthetic procedure can be successfully scaled up to produce practically useful amounts of pyrazole products within 2–5 hours.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)