Testrow, CP, Whittaker, DG, Holden, AV et al. (1 more author) (2017) Modelling the Effects of Nifedipine on Ventricular and Myometrial Cells of Pregnant Rats. In: 2016 Computing in Cardiology Conference (CinC). Computing in Cardiology, 11-14 Sep 2016, Vancouver, Canada. IEEE , pp. 829-832. ISBN 978-1-5090-0895-7
Abstract
In this study we have used computational models to investigate the effects of nifedipine on two different cell types; the rat ventricular cell and the rat myometrial cell. Nifedipine is a calcium-channel blocker commonly used by health services around the world to treat both cardiovascular conditions (such as high blood pressure) and as a tocolytic to treat pre-term birth. The latter usage is prohibited in pregnant patients with pre-existing heart conditions. By applying discrete blocks to the L-Type calcium channels in each cell model we were able to simulate the presence of nifedipine at varying concentrations. Using the electrical and ionic responses to blocking these channels as indicators, we have been able to quantify and describe the effects of nifedipine in each cell type and compare them qualitatively. Although any level of block will reduce the maximum level of intracellular calcium in the myometrial cell, a 60% block or higher is required to produce a change in the morphology of the calcium transient. It remains to be shown if the dose required to achieve this could result in a patient with a pre-existing heart condition experiencing hypotension or other pathological cardiac conditions during labor, if nifedipine is used as a tocolytic.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
Keywords: | Calcium, Heart, Computational modeling, Pregnancy, Rats, Blood pressure, Ions |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Oct 2016 14:10 |
Last Modified: | 18 Jul 2017 04:20 |
Status: | Published |
Publisher: | IEEE |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:106411 |