Atkinson, L, Basharat, A, Benson, AP orcid.org/0000-0003-4679-9842 et al. (4 more authors) (2017) Computational Modelling of Cardiac Electrophysiological Changes in Malarial Fever. In: Computing in Cardiology. Computing in Cardiology, 11-14 Sep 2016, Vancouver, Canada. IEEE , pp. 1097-1100. ISBN 978-1-5090-0895-7
Abstract
Cardiac function is impaired in severe malarial fever, and ECGs show changes associated with repolarization. These could contribute to mortality via ventricular arrhythmia. The cardiac effects could be due to the malarial parasite load in the heart, specific cardio-toxic effects of the parasite or cardio-toxic effects of antimalarial agents. We construct a simple 1-dimensional electrophysiological model for the physico-chemical changes clinically observed during malarial fever: with temperature, pH and [ionic]plasma changes. The model can quantitatively reproduce the tachycardia and QTc prolongation seen in the adult, and shortening seen in the child during malarial fever.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Oct 2016 13:50 |
Last Modified: | 21 Oct 2017 22:53 |
Published Version: | http://ieeexplore.ieee.org/document/7868938/ |
Status: | Published |
Publisher: | IEEE |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:106410 |