Figueira, I., Fernandes, A., Mladenovic, A. et al. (11 more authors) (2016) Interventions for age-related diseases: shifting the paradigm. Mechanisms of Ageing and Development , 160. pp. 69-92. ISSN 0047-6374
Abstract
Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/) |
Keywords: | Ageing; Multimorbidity; chronic diseases; geroprotectors; geroscience |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease |
Funding Information: | Funder Grant number COST OFFICE cost action BM1402 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Oct 2016 14:48 |
Last Modified: | 13 Dec 2016 12:02 |
Published Version: | https://dx.doi.org/10.1016/j.mad.2016.09.009 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.mad.2016.09.009 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:106227 |