Johnson, TC and Marsden, SP (2016) Precious-Metal-Free Heteroarylation of Azlactones: Direct Synthesis of α-Pyridyl, α-Substituted Amino Acid Derivatives. Organic Letters, 18 (20). pp. 5364-5367. ISSN 1523-7060
Abstract
A one-pot, three-component synthesis of α-pyridyl, α-substituted amino acid derivatives is described. The key transformation is a direct, precious-metal-free heteroarylation of readily available, amino acid derived azlactones with electrophilically activated pyridine N-oxides. The resulting intermediates can be used directly as efficient acylating agents for a range of nucleophiles, leading to the heteroarylated amino acid derivatives in a single vessel.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © 2016 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.6b02731. Uploaded in accordance with the publisher's self-archiving policy. |
| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 18 Oct 2016 09:36 |
| Last Modified: | 05 Oct 2017 18:26 |
| Published Version: | https://doi.org/10.1021/acs.orglett.6b02731 |
| Status: | Published |
| Publisher: | American Chemical Society |
| Identification Number: | 10.1021/acs.orglett.6b02731 |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:106086 |
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