Measurements of carbamazepine-succinic acid (CBZ-SCA) co-crystal flowability

Abstract

In pharmaceutical industry, the bulk powder properties will have greater affect during processing, leading to the significant financial losses if action on controlling the problems is not in place. In this study, the effects of particle size and morphology on powder flow properties of the carbamazepine-succinic acid (CBZ-SCA) co-crystal were investigated using a Dietmar Schulze Shear Cell tester. Result shows that CBZSCAhas a mean size of below 100 μm and has easy flowing powder behaviour.

Metadata

Item Type:	Article
Authors/Creators:	Abd Rahim, S Hammond, RB Roberts, KJ https://orcid.org/0000-0002-1070-7435 Sheikh, AY
Dates:	Published: March 2014 Published (online): 25 February 2014 Accepted: 29 January 2014
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) > Institute for Particle Science and Engineering (Leeds)
Funding Information:	Funder Grant number Abbott Laboratories Global Pharmaceutical R&D NOT GIVEN
Depositing User:	Symplectic Publications
Date Deposited:	15 Nov 2016 11:31
Last Modified:	16 Nov 2016 00:10
Published Version:	http://ajbasweb.com/old/ajbas/2014/Special/788-792...
Status:	Published
Publisher:	Australian Journal of Basic and Applied Sciences
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:106018

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Measurements of carbamazepine-succinic acid (CBZ-SCA) co-crystal flowability

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