Taylor, A.F. orcid.org/0000-0003-0071-8306, Tinsley, M.R. and Showalter, K. (2015) Insights into collective cell behaviour from populations of coupled chemical oscillators. Physical Chemistry Chemical Physics , 17 (31). pp. 20047-20055. ISSN 1463-9076
Abstract
Biological systems such as yeast show coordinated activity driven by chemical communication between cells. Here, we show how experiments with coupled chemical oscillators can provide insights into collective behaviour in cellular systems. Two methods of coupling the oscillators are described: exchange of chemical species with the surrounding solution and computer-controlled illumination of a light-sensitive catalyst. The collective behaviour observed includes synchronisation, dynamical quorum sensing (a density dependent transition to population-wide oscillations), and chimera states, where oscillators spontaneously split into coherent and incoherent groups. At the core of the different types of behaviour lies an intracellular autocatalytic signal and an intercellular communication mechanism that influences the autocatalytic growth.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 the Owner Societies. This is an author produced version of a paper subsequently published in Physical Chemistry Chemical Physics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Cells; Dictyostelium; Models, Biological; Myocardium; Quantum Theory; Quorum Sensing |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/K030574/2 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Oct 2016 14:19 |
Last Modified: | 23 Mar 2018 09:52 |
Published Version: | http://dx.doi.org/10.1039/c5cp01964h |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Refereed: | Yes |
Identification Number: | 10.1039/c5cp01964h |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:105441 |