Noy, Agnes orcid.org/0000-0003-0673-8949, Sutthibutpong, Thana and Harris, Sarah A. (2016) Protein/DNA interactions in complex DNA topologies: expect the unexpected. Biophysical Reviews. ISSN 1867-2450
Abstract
DNA supercoiling results in compacted DNA structures that can bring distal sites into close proximity. It also changes the local structure of the DNA, which can in turn influence the way it is recognised by drugs, other nucleic acids and proteins. Here, we discuss how DNA supercoiling and the formation of complex DNA topologies can affect the thermodynamics of DNA recognition. We then speculate on the implications for transcriptional control and the three-dimensional organisation of the genetic material, using examples from our own simulations and from the literature. We introduce and discuss the concept of coupling between the multiple length-scales associated with hierarchical nuclear structural organisation through DNA supercoiling and topology.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©The Author(s) 2016. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Physics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 29 Sep 2016 11:54 |
Last Modified: | 22 Jan 2025 00:07 |
Published Version: | https://doi.org/10.1007/s12551-016-0208-8 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1007/s12551-016-0208-8 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:105375 |
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