Persson, M, Fu, Y orcid.org/0000-0003-4972-0626, Bhattacharya, A et al. (6 more authors) (2016) Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis. Systematic Reviews, 5 (165). ISSN 2046-4053
Abstract
Background: Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) metaanalysis will be conducted. The study aims to investigate the relative treatment effects of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and topical capsaicin in OA and to identify patient-level predictors of treatment response. Methods: IPD will be collected from randomised controlled trials (RCTs) of topical NSAIDs and capsaicin in OA. Multilevel regression modelling will be conducted to determine predictors for the specific and the overall treatment effect. Discussion: Through the identification of treatment responders, this IPD meta-analysis may improve the current understanding of the pain mechanisms in OA and guide clinical decision-making. Identifying and prescribing the treatment most likely to be beneficial for an individual with OA will improve the efficiency of patient management.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Keywords: | Osteoarthritis, topical, NSAIDs, capsaicin, individual patient data meta-analysis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Healthcare (Leeds) > Midwifery (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Sep 2016 10:25 |
Last Modified: | 23 Jun 2023 22:14 |
Published Version: | http://dx.doi.org/%2010.1186/s13643-016-0348-8 |
Status: | Published |
Publisher: | BioMed Central |
Identification Number: | 10.1186/s13643-016-0348-8 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:105325 |