Spears, Richard James and Fascione, Martin Anthony orcid.org/0000-0002-0066-4419 (2016) Site-selective incorporation and ligation of protein aldehydes. Organic and Biomolecular Chemistry. pp. 7622-7638. ISSN 1477-0539
Abstract
The incorporation of aldehyde handles into proteins, and subsequent chemical reactions thereof, is rapidly proving to be an effective way of generating homogeneous, covalently linked protein constructs that can display a vast array of functionality. In this review, we discuss methods for introducing aldehydes into target proteins, and summarise the ligation strategies for site-selective modification of proteins containing this class of functional handles.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2016 |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 29 Sep 2016 11:07 |
Last Modified: | 29 Mar 2025 00:06 |
Published Version: | https://doi.org/10.1039/C6OB00778C |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/C6OB00778C |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:105157 |