Begg, GA orcid.org/0000-0001-5260-4293, Lip, GYL, Plein, S et al. (1 more author) (2017) Circulating biomarkers of fibrosis and cardioversion of atrial fibrillation: A prospective, controlled cohort study. Clinical Biochemistry, 50 (1-2). pp. 11-15. ISSN 0009-9120
Abstract
Introduction: External direct current cardioversion (DCCV) is an established treatment for AF but is associated with procedural risk and high AF recurrence rates. Cardiac fibrosis has been associated with AF, and circulating biomarkers have been suggested as a method of its assessment, but which biomarkers are suitable is yet to be determined. This study examines the differences between levels of procollagen type III N terminal peptide (PIIINP), type I collagen carboxyl telopeptide (ICTP), galectin-3 (gal-3) and fibroblast growth factor 23 (FGF-23) in DCCV patients, and disease-and-age-matched controls. Their predictive value for AF recurrence was analysed. Methods: 79 patients undergoing DCCV and 40 age-and-disease-matched controls were included. Biomarkers were analysed using ELISA. Linear regression was used to examine relationships between biomarker levels and baseline characteristics, including echocardiographic measurements. Cox regression was used to assess relationships between baseline characteristics, including biomarker levels, and AF recurrence. Results: There was no statistically significant difference between biomarker levels in the DCCV and control groups. Diabetes mellitus was related to higher FGF-23 (p=0.007) and PIIINP (p=0.027). Female sex (p=0.014), hypertension (p=0.001), and higher body mass index (p≤0.001) were related to higher gal-3 levels. FGF-23 was weakly predictive of AF recurrence (HR 1.003 p=0.012). Conclusion: PIIINP, ICTP, and Gal-3 are not predictive of AF recurrence after DCCV. FGF-23 may be associated with arrhythmia recurrence, but further work is required to clarify this. The presence of AF has no effect on levels of these biomarkers when compared to age and disease-matched controls.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. This is an author produced version of a paper published in Clinical Biochemistry. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Fibrosis; atrial fibrillation; biomarkers; cardioversion |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Funding Information: | Funder Grant number British Heart Foundation FS/10/062/28409 |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Sep 2016 15:09 |
Last Modified: | 12 Sep 2017 04:12 |
Published Version: | https://doi.org/10.1016/j.clinbiochem.2016.09.008 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.clinbiochem.2016.09.008 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:105048 |