Sorg, BA, Berretta, S, Blacktop, JM et al. (4 more authors) (2016) Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity. Journal of Neuroscience, 36 (45). pp. 11459-11468. ISSN 0270-6474
Abstract
Perineuronal nets (PNNs) are unique extracellular matrix (ECM) structures that wrap around certain neurons in the central nervous system (CNS) during development and control plasticity in the adult CNS. They appear to contribute to a wide range of diseases/disorders of the brain, are involved in recovery from spinal cord injury, and are altered during ageing, learning and memory, and after exposure to drugs of abuse. Here the focus is on how a major component of PNNs, chondroitin sulfate proteoglycans (CSPGs), control plasticity, and on the role of PNNs in memory in normal ageing, in a tauopathy model of Alzheimer’s disease, and in drug addiction. Also discussed is how altered ECM/PNN formation during development may produce synaptic pathology associated with schizophrenia, bipolar disorder, major depression, and autism spectrum disorders. Understanding the molecular underpinnings of how PNNs are altered in normal physiology and disease will offer insights into new treatment approaches for these diseases.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2016, the authors. This is an author produced version of a paper published in the Journal of Neuroscience. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | aging; Alzheimer’s; autism; chondroitin sulfate proteoglycans; drug abuse; extracellular matrix; memory; perineuronal nets; schizophrenia |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Sep 2016 12:24 |
Last Modified: | 18 Jul 2017 16:52 |
Published Version: | https://doi.org/10.1523/JNEUROSCI.2351-16.2016 |
Status: | Published |
Publisher: | Society for Neuroscience |
Identification Number: | 10.1523/JNEUROSCI.2351-16.2016 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104803 |