Finn-Sell, S.L., Renshall, L.J., Cowley, E.J. et al. (5 more authors) (2016) The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction. Placenta, 42. pp. 25-27. ISSN 0143-4004
Abstract
The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP+/+), heterozygous (ANP+/-) and knockout (ANP−/-) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), and fetal weight (E18.5) was unaffected. Placental weight was greater in ANP−/− versus ANP+/+ mice. Therefore, in our hands, the ANP model does not express phenotypic features of PE with FGR.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
Keywords: | Pre-eclampsia; Fetal growth restriction; Atrial natriuretic peptide; Mouse |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection and Immunity (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 16 Sep 2016 10:45 |
Last Modified: | 16 Sep 2016 10:45 |
Published Version: | http://dx.doi.org/10.1016/j.placenta.2016.04.003 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.placenta.2016.04.003 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104744 |