Picao-Osorio, J, Johnston, J orcid.org/0000-0002-9928-989X, Landgraf, M et al. (2 more authors) (2015) MicroRNA-encoded behavior in Drosophila. Science, 350 (6262). pp. 815-820. ISSN 0036-8075
Abstract
The relationship between microRNA (miRNA) regulation and the specification of behavior is only beginning to be explored.We found that mutation of a single miRNA locus (miR-iab4/iab8)inDrosophila larvae affects the animal’s capacity to correct its orientation if turned upside down (self-righting). One of the miRNA targets involved in this behavior is the Hox gene Ultrabithorax, whose derepression in two metameric neurons leads to self-righting defects. In vivo neural activity analysis reveals that these neurons, the self-righting node (SRN), have different activity patterns in wild type and miRNA mutants, whereas thermogenetic manipulation of SRN activity results in changes in self-righting behavior. Our work thus reveals a miRNA-encoded behavior and suggests that other miRNAs might also be involved in behavioral control in Drosophila and other species.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 by the American Association for the Advancement of Science. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science, Vol. 350, Issue 6262, on 13 Nov 2015, DOI: https://dx.doi.org/10.1126/science.aad0217 |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Sep 2016 13:51 |
Last Modified: | 01 Dec 2020 17:40 |
Published Version: | https://dx.doi.org/10.1126/science.aad0217 |
Status: | Published |
Publisher: | American Association for the Advancement of Science |
Identification Number: | 10.1126/science.aad0217 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104721 |