Chen, Y., Dall'Ara, E. orcid.org/0000-0003-1471-5077, Sales, E. et al. (4 more authors) (2017) Micro-CT based finite element models of cancellous bone predict accurately displacement once the boundary condition is well replicated: A validation study. Journal of the Mechanical Behavior of Biomedical Materials, 65. pp. 644-651. ISSN 1751-6161
Abstract
Non-destructive 3D micro-computed tomography (microCT) based finite element (microFE) models are used to estimate bone mechanical properties at tissue level. However, their validation remains challenging. Recent improvements in the quantification of displacements in bone tissue biopsies subjected to staged compression, using refined Digital Volume Correlation (DVC) techniques, now provide a full field displacement information accurate enough to be used for microFE validation. In this study, three specimens (two humans and one bovine) were tested with two different experimental set-ups, and the resulting data processed with the same DVC algorithm. The resulting displacement vector field was compared to that predicted by microFE models solved with three different boundary conditions (BC): nominal force resultant, nominal displacement resultant, distributed displacement. The first two conditions were obtained directly from the measurements provided by the experimental jigs, whereas in the third case the displacement field measured by the DVC in the top and bottom layer of the specimen was applied. Results show excellent relationship between the numerical predictions (x) and the experiments (y) when using BC derived from the DVC measurements (UX: y=1.07x-0.002, RMSE: 0.001 mm; UY: y=1.03x-0.001, RMSE: 0.001 mm; UZ: y=x+0.0002, RMSE: 0.001 mm for bovine specimen), whereas only poor correlation was found using BCs according to experiment setups. In conclusion, microFE models were found to predict accurately the vectorial displacement field using interpolated displacement boundary condition from DVC measurement.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | MicroCT; microFE; cancellous bone; DVC; validation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - FP6/FP7 MAMBO - 327357 ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/K03877X/1 NATIONAL CENTRE FOR THE REPLACEMENT, REFINEMENT AND REDUCTION OF ANIMALS IN RESEARCH NC/K000780/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 19 Sep 2016 09:56 |
Last Modified: | 06 Nov 2018 11:45 |
Published Version: | https://doi.org/10.1016/j.jmbbm.2016.09.014 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jmbbm.2016.09.014 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104683 |