Stewart, N.J., Parra-Robles, J. and Wild, J.M. orcid.org/0000-0002-7246-8660 (2016) Finite element modeling of 129Xe diffusive gas exchange NMR in the human alveoli. Journal of Magnetic Resonance, 271. pp. 21-33. ISSN 1090-7807
Abstract
Existing models of 129Xe diffusive exchange for lung microstructural modeling with time-resolved MR spectroscopy data have considered analytical solutions to one-dimensional, homogeneous models of the lungs with specific assumptions about the alveolar geometry. In order to establish a model system for simulating the effects of physiologically-realistic changes in physical and microstructural parameters on 129Xe exchange NMR, we have developed a 3D alveolar capillary model for finite element analysis. To account for the heterogeneity of the alveolar geometry across the lungs, we have derived realistic geometries for finite element analysis based on 2D histological samples and 3D micro-CT image volumes obtained from ex vivo biopsies of lung tissue from normal subjects and patients with interstitial lung disease. The 3D alveolar capillary model permits investigation of the impact of alveolar geometrical parameters and diffusion and perfusion coefficients on the in vivo measured 129Xe CSSR signal response. The heterogeneity of alveolar microstructure that is accounted for in image-based models resulted in considerable alterations to the shape of the 129Xe diffusive uptake curve when compared to 1D models. Our findings have important implications for the future design and optimization of 129Xe MR experiments and in the interpretation of lung microstructural changes from this data.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016 Elsevier. |
Keywords: | Hyperpolarized xenon-129; Gas exchange NMR; Finite element analysis; Human lung; Histological models |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL (EPSRC) EP/D070252/1 NATIONAL INSTITUTE FOR HEALTH RESEARCH NIHR-RP-R3-12-027 MEDICAL RESEARCH COUNCIL MR/M008894/1 MEDICAL RESEARCH COUNCIL MR/M008894/1 NATIONAL INSTITUTE FOR HEALTH RESEARCH NIHR-RP-R3-12-027 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 22 Jun 2017 09:34 |
Last Modified: | 22 Jun 2017 09:34 |
Published Version: | https://doi.org/10.1016/j.jmr.2016.07.016 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jmr.2016.07.016 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104629 |