Rothman, A.M., Rowlands, D.J. and Lawrie, A. orcid.org/0000-0003-4192-9505 (2016) miRNA-140-5p: new avenue for pulmonary arterial hypertension drug development? Epigenomics. ISSN 1750-1911
Abstract
Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Pathologically, PAH is characterised by sustained vasoconstriction and progressive obliteration of small pulmonary arteries through a process of medial thickening, intimal fibrosis and the formation of angioproliferative lesions. Current treatments target the sustained vasoconstriction via either the prostacyclin, endothelin or nitric oxide pathway but do little to address the underlying progressive proliferative vascular disease. Dysregulated expression of microRNA (miR) has been identified in PAH and we have recently highlighted reduced miR-140-5p in patients with PAH. Replacement of miR-140-5p attenuated disease in animal models with the regulation of Smurf1, a E3 ubiquitin ligase targeting BMPR2 as one identified mechanism. These data highlight Smurf1 inhibition as a treatment for PAH.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Future Medicine. This is an author produced version of a paper subsequently published in Epigenomics. Uploaded in accordance with the publisher's self-archiving policy |
Keywords: | SMURF1; miR140-5p; miRNA; pulmonary arterial hypertension; remodeling; ubiquitination |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number BRITISH HEART FOUNDATION FS/13/48/30453 MEDICAL RESEARCH COUNCIL MR/K002406/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Sep 2016 09:58 |
Last Modified: | 13 Sep 2017 10:28 |
Published Version: | http://dx.doi.org/10.2217/epi-2016-0089 |
Status: | Published |
Publisher: | Future Medicine |
Refereed: | Yes |
Identification Number: | 10.2217/epi-2016-0089 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104590 |