Ward, Jonathan S., Bray, Joshua T W orcid.org/0000-0003-2384-9675, Aucott, Benjamin J. et al. (6 more authors) (2016) Photoactivated functionizable tetracarbonyl phenylpyridine manganese(I) complexes as CO-releasing molecules:a direct Suzuki–Miyaura cross-coupling on a thermally-stable CO-RM. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. pp. 5044-5051. ISSN 1434-1948
Abstract
A new class of carbon monoxide-releasing molecules (CO-RMs) are reported based on a previously known tetracarbonyl phenylpyridine manganese(I) motif. A pre-functionalized CO-RM undergoes a direct Pd-catalysed Suzuki–Miyaura cross-coupling with phenylboronic acid to give a π-extended three-ring CO-RM. Cross-coupling conditions were modified to allow coupling of a morpholine-containing boronic acid on to a CO-RM, introducing drug-like functionality. An LED system was used to facilitate controlled CO-release. Irradiation using an LED (400 nm or 365 nm) gives rise to faster CO-release, with lower overall input power than traditional use of a TLC lamp (365 nm), as measured by an assay based on the conversion of deoxymyoglobin to carbonmonoxymyoglobin.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, John Wiley & Sons, Inc. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Keywords: | Carbon monoxide,Cross-coupling,Manganese,Photochemistry |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 08 Sep 2016 11:48 |
Last Modified: | 05 Dec 2024 00:13 |
Published Version: | https://doi.org/10.1002/ejic.201600775 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/ejic.201600775 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104528 |
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