Bruner-Tran, KL, Gnecco, J, Ding, T et al. (3 more authors) (2017) Exposure to the Environmental Endocrine Disruptor TCDD and Human Reproductive Dysfunction: Translating Lessons from Murine Models. Reproductive Toxicology, 68. pp. 59-71. ISSN 0890-6238
Abstract
Humans and other animals are exposed to a wide array of man-made toxicants, many of which act as endocrine disruptors that exhibit differential effects across the lifespan. In humans, while the impact of adult exposure is known for some compounds, the potential consequences of developmental exposure to endocrine disrupting chemicals (EDCs) is more difficult to ascertain. Animal studies have revealed that exposure to EDCs prior to puberty can lead to adult reproductive disease and dysfunction. Specifically, in adult female mice with an early life exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), we demonstrated a transgenerational occurrence of several reproductive diseases that have been linked to endometriosis in women. Herein, we review the evidence for TCDD-associated development of adult reproductive disease as well as known epigenetic alterations associated with TCDD and/or endometriosis. We will also introduce new "Organ-on-Chip" models which, combined with our established murine model, are expected to further enhance our ability to examine alterations in gene-environment interactions that lead to heritable disease.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016 Elsevier Inc. This is an author produced version of a paper published in Reproductive Toxicology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | TCDD; Transgenerational; Endometriosis; Adenomyosis; Preterm birth; Epigenetics |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Pollard Institute (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Sep 2016 10:55 |
Last Modified: | 25 Jul 2017 15:51 |
Published Version: | https://doi.org/10.1016/j.reprotox.2016.07.007 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.reprotox.2016.07.007 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104490 |