Gartland, A. orcid.org/0000-0002-3712-2437, Erler, J.T. and Cox, T.R. (2016) The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis. Journal of Bone Oncology. ISSN 2212-1374
Abstract
Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the primary site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour. This review provides an overview of the current understanding on the role of role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis. .
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2016 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Funding Information: | Funder Grant number BREAST CANCER CAMPAIGN 2012MayPR086 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 07 Sep 2016 12:29 |
Last Modified: | 07 Sep 2016 12:29 |
Published Version: | http://dx.doi.org/10.1016/j.jbo.2016.04.001 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jbo.2016.04.001 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104468 |