Martell-Pelletier, J, Barr, AJ, Cicuttini, FM et al. (7 more authors) (2016) Osteoarthritis. Nature Reviews Disease Primers, 2. 16072. ISSN 2056-676X
Abstract
Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing socioeconomic impact owing to the ageing population and mainly affects the diarthrodial joints. Primary OA results from a combination of risk factors, with increasing age and obesity being the most prominent. The concept of the pathophysiology is still evolving, from being viewed as cartilage-limited to a multifactorial disease that affects the whole joint. An intricate relationship between local and systemic factors modulates its clinical and structural presentations, leading to a common final pathway of joint destruction. Pharmacological treatments are mostly related to relief of symptoms and there is no disease-modifying OA drug (that is, treatment that will reduce symptoms in addition to slowing or stopping the disease progression) yet approved by the regulatory agencies. Identifying phenotypes of patients will enable the detection of the disease in its early stages as well as distinguish individuals who are at higher risk of progression, which in turn could be used to guide clinical decision making and allow more effective and specific therapeutic interventions to be designed. This Primer is an update on the progress made in the field of OA epidemiology, quality of life, pathophysiological mechanisms, diagnosis, screening, prevention and disease management.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This is an author produced version of a paper published in Nature Reviews Disease Primers. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Ageing; Bone imaging; Musculoskeletal system; Obesity; Osteoarthritis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Sep 2016 12:15 |
Last Modified: | 05 Nov 2017 01:05 |
Published Version: | https://dx.doi.org/10.1038/nrdp.2016.72 |
Status: | Published |
Publisher: | Nature Publishing Group |
Identification Number: | 10.1038/nrdp.2016.72 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104411 |