Smith, IL, Brown, S orcid.org/0000-0002-1840-3786, Nixon, J orcid.org/0000-0003-1705-7698 et al. (11 more authors) (2017) Treatment of severe, chronic hand eczema. Results from a UK-wide survey. Clinical and Experimental Dermatology, 42 (2). pp. 185-188. ISSN 0307-6938
Abstract
Treatment of severe hand eczema (HE) which is resistant to topical potent corticosteroid treatment is challenging. In 2013 we surveyed 194 UK dermatologists to obtain information about usual treatment pathways to inform the choice of the comparator in a trial of alitretinoin in severe HE (ALPHA trial); the results indicate that treatment approaches differ among UK dermatologists. Psoralen combined with ultraviolet A (PUVA) and alitretinoin were identified as the most frequent first line treatment options for hyperkeratotic HE, whereas oral corticosteroids were identified as frequent first line treatment for vesicular HE, followed by PUVA and alitretinoin. In terms of potential side effects of long-term or repeated use, oral steroids and ciclosporin A were reported to cause most concerns. There is uncertainty about which treatment gives the best short and long-term outcome due to a lack of definitive randomised controlled trials evaluating the effectiveness of different treatment pathways in severe HE.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 British Association of Dermatologists. This is the peer reviewed version of the following article: "Smith, I. L., Brown, S., Nixon, J., Cowdell, F. C., Ersser, S., Fernandez, C., Goodfield, M., Green, C. M., Hampton, P., Lear, J. T., Smith, C. H., Sunderland, L., Tubeuf, S. and Wittmann, M. (2017), Treatment of severe, chronic hand eczema: results from a UK-wide survey. Clin Exp Dermatol, 42: 185–188. doi:10.1111/ced.13015" which has been published in final form at https://doi.org/10.1111/ced.13015. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | Hand eczema; Alitretinoin; PUVA; Dermatitis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Healthcare (Leeds) > Nursing Adult (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Health Economics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Sep 2016 12:40 |
Last Modified: | 02 Dec 2017 01:38 |
Published Version: | https://doi.org/10.1111/ced.13015 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/ced.13015 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104211 |