Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages

Abstract

Recent advances suggest that there is a stochastic contribution to the proliferation and fate choice of retinal progenitors. How does this stochasticity fit with the progression of temporal competence and the transcriptional hierarchies that also influence cell division and cell fate in the developing retina? Where may stochasticity arise in the system and how do we make progress in this field when we may never fully explain the behavior of individual progenitor cells?

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Item Type:	Article
Authors/Creators:	Boije, H. MacDonald, R.B. https://orcid.org/0000-0003-4194-8925 Harris, W.A.
Copyright, Publisher and Additional Information:	Copyright © 2014 The Authors. Published by Elsevier Ltd. Under a Creative Commons license (https://creativecommons.org/licenses/by/3.0/).
Dates:	Published: August 2014 Published (online): 15 March 2014
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	30 Aug 2016 14:58
Last Modified:	30 Aug 2016 14:58
Published Version:	http://dx.doi.org/10.1016/j.conb.2014.02.014
Status:	Published
Publisher:	Elsevier
Refereed:	Yes
Identification Number:	10.1016/j.conb.2014.02.014
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:104196

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Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages

Abstract

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