Jokl, Elliot J and Blanco, Gonzalo orcid.org/0000-0003-3827-3111 (2016) Disrupted autophagy undermines skeletal muscle adaptation and integrity. Mammalian genome : official journal of the International Mammalian Genome Society. ISSN 1432-1777
Abstract
This review assesses the importance of proteostasis in skeletal muscle maintenance with a specific emphasis on autophagy. Skeletal muscle appears to be particularly vulnerable to genetic defects in basal and induced autophagy, indicating that autophagy is co-substantial to skeletal muscle maintenance and adaptation. We discuss emerging evidence that tension-induced protein unfolding may act as a direct link between mechanical stress and autophagic pathways. Mechanistic links between protein damage, autophagy and muscle hypertrophy, which is also induced by mechanical stress, are still poorly understood. However, some mouse models of muscle disease show ameliorated symptoms upon effective targeting of basal autophagy. These findings highlight the importance of autophagy as therapeutic target and suggest that elucidating connections between protein unfolding and mTOR-dependent or mTOR-independent hypertrophic responses is likely to reveal specific therapeutic windows for the treatment of muscle wasting disorders.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2016 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 26 Aug 2016 15:24 |
Last Modified: | 16 Oct 2024 13:14 |
Published Version: | https://doi.org/10.1007/s00335-016-9659-2 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1007/s00335-016-9659-2 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104146 |
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