O'Shea, SJ orcid.org/0000-0002-1588-6022, Davies, JR and Newton-Bishop, JA (2016) Vitamin D, Vitamin A, the primary melanoma transcriptome and survival. British Journal of Dermatology, 175 (S2). pp. 30-34. ISSN 0007-0963
Abstract
Survival from melanoma is influenced by several, well-established clinical and histopathological factors, e.g. age, Breslow thickness and microscopic ulceration. We (the Section of Epidemiology and Biostatistics, University of Leeds) have carried out research to better understand the biological basis for these observations. Preliminary results indicated a protective role for vitamin D in melanoma relapse and that higher vitamin D was associated with thinner primary melanomas. Funding from the British Skin Foundation enabled JNB to establish a study of the effects of vitamin A in melanoma. The results suggested that vitamin A could reduce the protective effect of vitamin D in terms of overall survival. Therefore, we propose that vitamin D3 supplementation alone might be preferable to combined multivitamin preparations, where vitamin D supplementation is deemed to be appropriate. Proving a causal link between vitamin D and melanoma-specific survival is challenging. We have shown limited evidence of causation in a Mendelian randomization experiment (described in more detail later). Recent work in Leeds has also shown that higher vitamin D may be protective for microscopic ulceration. Taken together, vitamin D appears to be associated with less aggressive primary melanomas and may itself influence outcome. We continue to explore the role of vitamin D in melanoma survival and the optimum levels that might be crucial.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Epidemiology and Biostatistics (Leeds) |
Funding Information: | Funder Grant number British Skin Foundation S501 Cancer Research UK c588/A19167 |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Sep 2016 09:04 |
Last Modified: | 05 Oct 2017 16:27 |
Published Version: | https://dx.doi.org/10.1111/bjd.14919 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/bjd.14919 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:104023 |