Peckham, M orcid.org/0000-0002-3754-2028 (2016) How myosin organization of the actin cytoskeleton contributes to the cancer phenotype. Biochemical Society Transactions, 44 (4). pp. 1026-1034. ISSN 0300-5127
Abstract
The human genome contains 39 genes that encode myosin heavy chains, classified on the basis of their sequence similarity into 12 classes. Most cells express at least 12 different genes, from at least 8 different classes, which are typically composed of several class 1 genes, at least one class 2 gene and classes 5, 6, 9, 10, 18 and 19. Although the different myosin isoforms all have specific and non-overlapping roles in the cell, in combination they all contribute to the organization of the actin cytoskeleton, and the shape and phenotype of the cell. Over (or under) expression of these different myosin isoforms can have strong effects on actin organization, cell shape and contribute to the cancer phenotype as discussed in this review.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society. This is an author produced version of a paper published in Biochemical Society Transactions. The final version of record is available at http://dx.doi.org/10.1042/BST20160034 |
Keywords: | actin; cytoskeleton; myosin |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) |
Funding Information: | Funder Grant number Yorkshire Cancer Research LPP044 |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Aug 2016 10:17 |
Last Modified: | 28 Aug 2017 02:48 |
Published Version: | http://dx.doi.org/10.1042/BST20160034 |
Status: | Published |
Publisher: | Portland Press |
Identification Number: | 10.1042/BST20160034 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:103762 |