Almela, T., Brook, I.M. and Moharamzadeh, K. (2016) The Significance of Cell-related Challenges in the Clinical Application of Tissue Engineering. Journal of Biomedical Materials Research Part A , 104 (12). pp. 3157-3163. ISSN 1549-3296
Abstract
Tissue engineering is increasingly being recognized as a new approach that could alleviate the burden of tissue damage currently managed with transplants or synthetic devices. Making this novel approach available in the future for patients who would potentially benefit is largely dependent on understanding and addressing all those factors that impede the translation of this technology to the clinic. Cell-associated factors in particular raise many challenges, including those related to cell sources, up- and downstream techniques, preservation, and the creation of in vitro microenvironments that enable cells to grow and function as far as possible as they would in vivo. This paper highlights the main confounding issues associated with cells in tissue engineering and how these issues may hinder the advancement of therapeutic tissue engineering. This article is protected by copyright. All rights reserved.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Wiley. This is an author produced version of a paper subsequently published in Journal of Biomedical Materials Research Part A. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | cell manufacturing; clinical applications; stem cells; tissue culture; tissue engineering |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 Aug 2016 11:48 |
Last Modified: | 10 Aug 2017 02:08 |
Published Version: | https://dx.doi.org/10.1002/jbm.a.35856 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/jbm.a.35856 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:103705 |