Beccani, M, Aiello, G, Gkotsis, N et al. (7 more authors) (2016) Component based design of a drug delivery capsule robot. Sensors and Actuators A: Physical, 245. pp. 180-188. ISSN 0924-4247
Abstract
Since the introduction of Wireless Capsule Endoscopy (WCE) researchers have started exploring the design space of Medical Capsule Robots (MCRs): embedded micro-systems that can operate autonomously within the human body and can diagnose, prevent, monitor, and cure diseases. Although the research in the area of MCRs is an active topic and has grown exponentially, current devices provide only limited functionalities because their design process is expensive and time consuming. To open this research field to a wider community and, at the same time, create better designs through advanced tool support, in our previous works we presented a design environment for the rapid development of MCRs. In this paper, this environment was adopted to design a Drug Delivery Capsule (DDC) based on a coil-magnet-piston mechanism. The force of the coil acting on the magnetic piston and the drug release profile were modeled and assessed on bench-top with a maximum relative error below 5%. Then, in vivo trials were performed to validate the DDC functionality with a scheduled drug release profile for a 5 h and 24 min procedure. The resulting design environment template is available open source for further development of drug delivery applications as well as to serve as guideline in prototyping novel MCRs addressing other clinical needs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2016, Elsevier B.V. All rights reserved. This is an author produced version of a paper published in Sensors and Actuators A: Physical. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Surgical robotics; Medical cyber-physical systems; Drug delivery; Medical Capsule Robots; Design environment; Embedded micro-systems |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Aug 2016 11:03 |
Last Modified: | 19 Jul 2017 09:50 |
Published Version: | http://doi.org/10.1016/j.sna.2016.04.035 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.sna.2016.04.035 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:103454 |